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Background & objective: Due to the features such as intuitive graphical appearance, ease of perception and straightforward applicability, risk matrix has become as one of the most used risk assessment tools.On the other hand, features such as the lack of precision in the classification of risk index, as well as subjective computational process, has
In order to characterize the genetic architecture of epilepsy in a pediatric population from the Iberian Peninsula (including the Canary Islands), we conducted targeted exome sequencing of 246 patients with infantile-onset seizures with or without Accessories neurodevelopmental delay.We detected 107 variants in 48 different genes, which were implic
Ferroptosis is a type of programmed cell death resulting from iron overload-dependent lipid peroxidation, and could be promoted by activating transcription factor 3 (ATF3).SIRT1 is an enzyme accounting for removing acetylated lysine residues from target proteins by consuming NAD+, but its role remains elusive in ferroptosis and activating ATF3.In t